SAT-246 Global Burden and Trend of Cardiovascular Disease Attributable to High LDL Cholesterol in Latin America and Caribbean from 1990-2021: An insight from the Global Burden of Disease Study 2021.

Abstract Disclosure: A. Bhalodia: None. K. Shah: None. R. Daoud: None. M. Kaur: None. G. Gopi: None. A. Rangani: None. V. Chenna: None. R. Dudhat: None. K.H. Patel: None. V.P. Amin: None. H.D. Desai: None. Introduction: Cardiovascular disease (CVD) remains the leading cause of death and disability in Latin America (LA) and the Caribbean, exerting a significant toll on public health systems and economic stability. High levels of LDL cholesterol are a major contributing factor to the incidence and progression of these diseases. This study aims to analyze the trends and regional disparities in the CVD burden attributable to high LDL cholesterol from 1990 to 2021, providing insights for targeted preventive measures. Method: We estimated deaths, disability adjusted life years (DALYs), and years lived with disability (YLDs) due to CVD attributable to high LDL by age, sex, year and location across the LA and Caribbean from 1990-2021 using global burden of disease study 2021. Results: Between 1990 and 2021, deaths due to CVD attributable to high LDL cholesterol increased from 115,688 (95% uncertainty interval: 69,810-162,451) to 207,027 (127,246-291,152), DALYs rose from 3 million (2-4 million) to 5 million (3.3-6.7 million), and YLDs increased from 99,898 (52,262-151,746) to 233,786 (123,006-357,585). Regionally, Tropical Latin America observed the largest decline in the annual percentage change (APC) of age-standardized mortality rates (ASMR) by 2.41%, DALYs rate (ASDALR) by 2.29%, and YLDs rate (ASYLDR) by 0.64% over the period. Nationally, Honduras experienced the most significant increase in APC for ASMR at 1.25%, with other countries showing declines. For ASDALR, Honduras again showed the highest increase at 0.88%, followed by the Dominican at 0.22%, while other countries noted decreases. Increases in ASYLDR were highest in the Dominican Republic (0.42%), Peru (0.2%), the United States Virgin Islands (0.1%), Guatemala (0.08%), Jamaica (0.06%), Dominica (0.04%), and Haiti (0.017%). Age-wise, the 20-54 age group saw a 45% total percentage change (TPC) in deaths and an 88% increase in YLDs, while the 55+ age group experienced an 88% rise in deaths and a 164% increase in YLDs. In terms of gender, males showed a higher overall increase in burden over the last three decades compared to females, with TPCs in deaths at 80% for males versus 78% for females, DALYs at 70% versus 63%, and YLDs at 138% versus 129%. Conclusion: The study underscores a significant rise in the burden of CVD attributable to high LDL cholesterol from 1990 to 2021, with marked increases in deaths, DALYs, and YLDs in LA and Caribbean. Notably, Tropical Latin America showed the most substantial declines in age-standardized rates, reflecting successful regional health interventions. Conversely, countries like Honduras and the Dominican Republic experienced increases in these metrics, suggesting targeted areas for enhanced cholesterol management strategies. This temporal and regional variation in disease burden highlights the ongoing need for focused public health initiatives to address hyperlipidemia effectively. Presentation: Saturday, July 12, 2025