SUN-393 Trends in Patients Hospitalized with Post-Procedural Hypothyroidism in the US From 2010-2019

Abstract Disclosure: D. Cornejo Gonzalez: None. M. Cuartas Mesa: None. E. Martinez Trevino: None. H. Shaka: None. Z. Aldeen: None. N. Al-Hashemi: None. K. Okonkwo: None. N. Krueger: None. Background: Post-procedural hypothyroidism is an iatrogenic cause of overt primary hypothyroidism, characterized by elevated serum TSH and low T4 levels. It primarily results from thyroid surgical resection, radioiodine therapy, or external irradiation. Recent trends in hospitalizations for this condition in the U.S. have not been fully explored. This study aims to examine trends in outcomes, costs, and demographic variables among patients hospitalized with post-procedural hypothyroidism over a recent 10-year period. Methods: A retrospective longitudinal analysis was conducted using the National Inpatient Sample (NIS) database to examine hospital admissions for post-procedural hypothyroidism from 2010 to 2019. Trends in primary in-hospital outcomes, including mortality, length of stay (LOS), and total hospitalization charges (THC), were assessed. Patients were identified using ICD-10 codes, and regression analysis was performed to adjust for age, sex, and race. Results: Between 2010 and 2019, there were 7,766 hospital admissions for post-procedural hypothyroidism. Among these patients, approximately 80% were female, the average age was 65 years, and the majority (70%) were of white ethnicity. Since 2010, total hospitalizations have significantly increased from 800 in 2010 to 880 in 2019 (p < 0.001). Notably, the inpatient mortality rate remained stable, from 1.6% in 2010 to 1.7% in 2019 (p = 0.365). There was a significant increase in mean THC over the study period, from $45,420.64 in 2010 to $62,455.96 in 2019 (p < 0.001). The trend in LOS was not statistically significant. Conclusion: The increasing number of hospitalizations and rising mean THC associated with post-procedural hypothyroidism highlight a growing burden on the healthcare system. However, the stability of inpatient mortality and LOS suggests that despite higher admissions and costs, patient outcomes have remained unchanged. Further research is warranted to identify factors driving cost increases and to explore strategies for optimizing resource utilization. Presentation: Sunday, July 13, 2025