Efficacy and safety of novel alginate-based sealants (SEAL-G and SEAL-G MIST) in reducing anastomotic leakage following colorectal anastomosis: a prospective multicenter study
Alginate-based sealants show promise in reducing the severity of anastomotic leaks and in supporting anastomotic healing, demonstrating high technical success and low complication rates. Trial registration: ClinicalTrials.gov iden-tifier: NCT04532515.
Authors
- Antonino Spinelli (ORCID: https://orcid.org/0000-0002-1493-1768)
- Mordechai Shimonov (ORCID: https://orcid.org/0000-0003-3700-0656)
- Isacco Montroni (ORCID: https://orcid.org/0000-0002-3769-8428)
- Matthew G. Tutton (ORCID: https://orcid.org/0000-0003-1191-2219)
- Oded Zmora (ORCID: https://orcid.org/0000-0001-6959-2006)
- David George Jayne (ORCID: https://orcid.org/0000-0002-8725-3283)
- Hagit Tulchinsky (ORCID: https://orcid.org/0000-0002-7717-1196)
- Lior Segev (ORCID: https://orcid.org/0000-0001-7972-9424)
- Fahim Kanani (ORCID: https://orcid.org/0009-0001-9754-5028)
- Ron Lavy (ORCID: https://orcid.org/0000-0002-4874-3028)
- Moshe Kamar
Institutions
- Hackensack University Medical Center (US)
- Humanitas University (IT)
- Sheba Medical Center (IL)
- Wolfson Medical Center (IL)
- St James's University Hospital (GB)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Colchester Hospital (GB)
- Colorectal Surgical Associates (US)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Annals of Coloproctology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3393/ac.2025.00297.0042
- Citations
- 1
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.05