Commissioning, Characterization, and First High-Dose-Rate Irradiations at a Compact X-Ray Tube for Microbeam and Minibeam Radiation Therapy
We successfully constructed and commissioned the first proof-of-concept LFXT prototype. Dosimetric characterizations of the achieved microbeam field showed the superiority of the LFXT compared with conventional x-ray tubes in terms of beam quality. In future developments, the remaining limitations of the prototype will be addressed, paving the way for improved minibeam and first ever microbeam radiation therapy in a clinical setting.
Authors
- Anton Dimroth (ORCID: https://orcid.org/0000-0002-7882-809X)
- Susanne Raulefs
- Jan J. Wilkens (ORCID: https://orcid.org/0000-0002-1851-0581)
- Stephanie E. Combs (ORCID: https://orcid.org/0000-0002-5233-1536)
- Ghaleb Natour (ORCID: https://orcid.org/0000-0002-8068-8989)
- Thomas E. Schmid (ORCID: https://orcid.org/0000-0002-8894-8087)
- Thomas Beiser
- Kurt Aulenbacher (ORCID: https://orcid.org/0000-0001-5433-7424)
- Franz Schilling (ORCID: https://orcid.org/0000-0001-5239-4628)
- Christian Petrich (ORCID: https://orcid.org/0000-0002-5002-4719)
- Johanna Winter (ORCID: https://orcid.org/0000-0002-3825-399X)
- Monika Dehn
- Stefan Bartzsch (ORCID: https://orcid.org/0000-0001-9550-9122)
- J Stolz
- Jacopo Frignani
Institutions
- GSI Helmholtz Centre for Heavy Ion Research (DE)
- Forschungszentrum Jülich (DE)
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Helmholtz Zentrum München (DE)
- Heinz Maier-Leibnitz Zentrum (DE)
- Helmholtz Institute Mainz (DE)
- Jülich Aachen Research Alliance (DE)
- Technical University of Munich (DE)
- FH Aachen (DE)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.10.012
- Citations
- 1
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Forschungszentrum Jülich