Adenosine A2A receptor modulation affects the development of depressive-like behaviour and dopamine D2 receptor availability in rats exposed to repeated social defeat
Our study showed that the treatment with either an A<sub>2A</sub>R agonist or an A<sub>2A</sub>R antagonist prevented the development of depressive-like behaviour, and reduced the availability of D<sub>2</sub> receptor in the striatum after exposure to RSD most likely by modulating the receptor affinity.
Authors
- Erik F. J. de Vries (ORCID: https://orcid.org/0000-0002-6915-1590)
- Cyprien G.J. Guerrin (ORCID: https://orcid.org/0000-0003-2312-5570)
- Daniel A. Vazquez-Matias (ORCID: https://orcid.org/0000-0001-7506-199X)
- Janine Doorduin (ORCID: https://orcid.org/0000-0003-2925-9959)
- Kavya Prasad (ORCID: https://orcid.org/0000-0002-6086-8667)
- Stéphanie Henry (ORCID: https://orcid.org/0000-0002-4704-4647)
Institutions
- University Medical Center Groningen (NL)
Publication Details
- Journal
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.pnpbp.2025.111540
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58