<scp>FLVCR1</scp> Deficiency Impairs Mitochondrial Homeostasis in Retinal Degeneration: Choline as a Potential Therapy
We developed two innovative mouse models and revealed that FLVCR1 is critical for maintaining mitochondrial homeostasis and supporting photoreceptor survival. Choline supplementation serves as a therapeutic intervention for RP caused by FLVCR1 mutations.
Authors
- Qianxiong He
- Lin Zhang (ORCID: https://orcid.org/0000-0003-2298-500X)
- Xianjun Zhu (ORCID: https://orcid.org/0000-0002-2531-7552)
- Hongjing Li (ORCID: https://orcid.org/0000-0002-7094-2680)
- Rong Zou
- Yi Wang (ORCID: https://orcid.org/0009-0006-7031-1252)
- Jinrui Cai
- Yan Gao
Institutions
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- Qinghai Tibetan Hospital (CN)
- Dazhou Central Hospital (CN)
Publication Details
- Journal
- Clinical and Experimental Ophthalmology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1111/ceo.70014
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00