Esketamine relieves depressive-like behaviors in MPTP-induced Parkinson disease mice via GPR109A-dependent reduction of neuroinflammation
Esketamine alleviates PD-related depressive-like behavior by suppressing microglial inflammation in the mPFC via GPR109A. These findings emphasise the importance of GPR109A in linking immune modulation to the rapid behavioral effects of esketamine, and indicate the need for further research into GPR109A-targeted treatments for PD-related depression.
Authors
- Shu Wang (ORCID: https://orcid.org/0000-0002-5914-0804)
- Chen Wang (ORCID: https://orcid.org/0000-0003-2306-9089)
- Wei Tan (ORCID: https://orcid.org/0009-0002-6650-5987)
- Yuanyuan Gao (ORCID: https://orcid.org/0000-0002-1695-0882)
- Song Wei (ORCID: https://orcid.org/0000-0002-2422-1903)
- Lin Ji
Institutions
- Suzhou Municipal Hospital (CN)
- Yancheng Third People's Hospital (CN)
- Yancheng Second People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111595
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00