Vitamin D pathway as a multi-level predictor of COVID-19 severity and mortality: Integrating serum levels, FokI (rs2228570) VDR polymorphism, and lung tissue expression

This study indicates that serum vitamin D levels, VDR gene polymorphism (rs2228570), and lung tissue VDR expression are strongly correlated with the severity and mortality of COVID-19. These findings validate the clinical use of vitamin D and VDR profiling may have associative markers and prospective treatment targets in the management of COVID-19.

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Publication Details

Journal
The Journal of Steroid Biochemistry and Molecular Biology
Published
2025-10-23
DOI
https://doi.org/10.1016/j.jsbmb.2025.106879
Primary Topic
Vitamin D Research Studies
Type
article
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article

Vitamin D pathway as a multi-level predictor of COVID-19 severity and mortality: Integrating serum levels, FokI (rs2228570) VDR polymorphism, and lung tissue expression

Harem Khdir Awla, Christer Janson, Raya Kh. Yashooa, Shukur Wasman Smail et al.
The Journal of Steroid Biochemistry and Molecular Biology
Vitamin D Research Studies
article

Vitamin D pathway as a multi-level predictor of COVID-19 severity and mortality: Integrating serum levels, FokI (rs2228570) VDR polymorphism, and lung tissue expression

Harem Khdir Awla, Christer Janson, Raya Kh. Yashooa, Shukur Wasman Smail, Shwan Ali Omar, Rebaz Hamza Salih, Baghawan Ahmed Othman, Asmaa Ameen Ghareeb, Dawan Dlshad Rafeeq
article en

Abstract

This study indicates that serum vitamin D levels, VDR gene polymorphism (rs2228570), and lung tissue VDR expression are strongly correlated with the severity and mortality of COVID-19. These findings validate the clinical use of vitamin D and VDR profiling may have associative markers and prospective treatment targets in the management of COVID-19.

The Journal of Steroid Biochemistry and Molecular BiologyVol. 255
Cihan University-Erbil (IQ), Uppsala University Hospital (SE), Kurdistan Regional Government (IQ), University of Kurdistan Hewler (IQ), University of Al-Qadisiyah (IQ), Salahaddin University-Erbil (IQ), Koya University (IQ)
Openalex Percentile: Top 58%
Vitamin D Research Studies
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Vitamin D pathway as a multi-level predictor of COVID-19 severity and mortality: Integrating serum levels, FokI (rs2228570) VDR polymorphism, and lung tissue expression — Harem Khdir Awla, Christer Janson, et al. · The Journal of Steroid Biochemistry and Molecular Biology (2025) | TGRS Research Map | TGRS