Periodontal Disease Independently Associated With White Matter Hyperintensity Volume
White matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and lacunar infarcts are radiographic markers of cerebral small vessel disease (CSVD), which is associated with an increased risk of stroke and cognitive decline. Periodontal disease (PD), a chronic inflammatory condition, has been linked to vascular pathology and may contribute to CSVD. The aim of this study was to assess the independent association between PD and MRI-verified CSVD features using data from the Atherosclerosis Risk in Communities (ARIC) cohort.
Authors
- Jaclyn Meyer (ORCID: https://orcid.org/0000-0001-9910-8086)
- Heather Shaw Bonilha (ORCID: https://orcid.org/0000-0002-3581-4202)
- Souvik Sen (ORCID: https://orcid.org/0000-0002-0886-2364)
- Chylee Martin
- Ryan T. Demmer (ORCID: https://orcid.org/0000-0003-3429-0379)
- Bruce A. Wasserman (ORCID: https://orcid.org/0000-0001-8458-1778)
- Wayne D. Rosamond (ORCID: https://orcid.org/0000-0001-5271-074X)
- Forrest Lowe
- James D. Beck (ORCID: https://orcid.org/0000-0001-5415-8311)
- Scott J. Wood (ORCID: https://orcid.org/0000-0002-2603-7552)
- Hamdi S Adam (ORCID: https://orcid.org/0000-0001-9655-7628)
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Maryland, Baltimore (US)
- University of Minnesota (US)
- University of Maryland Medical Center (US)
- University of South Carolina (US)
- Twin Cities Orthopedics (US)
Publication Details
- Journal
- Neurology Open Access
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1212/wn9.0000000000000037
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47