Non-polar components in PM2.5 increase matrix remodeling of CRS by up-regulating CEMIP in nasal fibroblasts
N-OC in PM<sub>2.5</sub>, especially PAHs, can aggravate CRS by activating hNFs through CEMIP. This study provides new ideas for exploring the pathogenic mechanism of air pollution on upper respiratory diseases.
Authors
- Yuelong Gu
- Ru Tang (ORCID: https://orcid.org/0000-0002-1464-2544)
- Hai Lin (ORCID: https://orcid.org/0000-0001-8383-469X)
- Jiayao Zhou
- Ying‐Jie Zhu (ORCID: https://orcid.org/0000-0002-5044-5046)
- Zhipeng Li (ORCID: https://orcid.org/0000-0002-6691-4070)
- Huilin Hu (ORCID: https://orcid.org/0000-0003-1619-4682)
- Shiyao Zhang (ORCID: https://orcid.org/0000-0001-8871-0215)
- Song Mao (ORCID: https://orcid.org/0000-0003-0236-656X)
- Shilei Pu
- Yue Zhao
- Weitian Zhang (ORCID: https://orcid.org/0009-0004-9263-4226)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Sixth People's Hospital (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fgene.2025.1672729
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China