Modular magnetic microrobot system for robust endoluminal navigation and high–radial force stent delivery in complex ductal anatomy

Endoluminal stent implantation is a common intervention strategy for treating obstructive lesions, but conventional delivery systems struggle to reach deep, tortuous ducts. To overcome this limitation, we present a magnetically controlled microrobot that integrates two functional modules: a magnetic actuation (MA) module for agile navigation and an ultrasound-responsive self-expanding stent module (ST module) for lesion-specific dilation. The system uses a dynamically tunable assembly mechanism governed by rotational direction enabling integrated locomotion (clockwise) and on-demand module separation (counterclockwise) at stenotic sites. The platform is compatible with intraoperative ultrasound, allowing real-time navigation and thermally triggered expansion in physiological environments. By synergizing programmable magnetic actuation, ultrasound-mediated expansion, and clinical workflow compatibility, the robot can navigate tortuous phantom ducts, achieving controlled stent deployment within 3 seconds and complete expansion within 30 seconds, permitting minimally invasive treatment of biliary strictures. This work advances microrobotic stent delivery by overcoming key barriers to clinical translation in endoluminal interventions.

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Publication Details

Journal
Science Advances
Published
2025-10-22
DOI
https://doi.org/10.1126/sciadv.ady4339
Citations
1
Primary Topic
Micro and Nano Robotics
Type
article
Field-Weighted Citation Impact
1.26
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article

Modular magnetic microrobot system for robust endoluminal navigation and high–radial force stent delivery in complex ductal anatomy

Xing Ma, Yihang Jiang, Bo Hao, Dongdong Jin et al.
1 citations
Science Advances
Micro and Nano Robotics
1.26
article

Modular magnetic microrobot system for robust endoluminal navigation and high–radial force stent delivery in complex ductal anatomy

Xing Ma, Yihang Jiang, Bo Hao, Dongdong Jin, Jacqueline Pui Wah Chung, Kai Fung Chan, Qinglong Wang, Lin Su, Philip Wai Yan Chiu, Haojin Yang, Xin Wang, Li Zhang, Neng Xia
article en
1 citations

Abstract

Endoluminal stent implantation is a common intervention strategy for treating obstructive lesions, but conventional delivery systems struggle to reach deep, tortuous ducts. To overcome this limitation, we present a magnetically controlled microrobot that integrates two functional modules: a magnetic actuation (MA) module for agile navigation and an ultrasound-responsive self-expanding stent module (ST module) for lesion-specific dilation. The system uses a dynamically tunable assembly mechanism governed by rotational direction enabling integrated locomotion (clockwise) and on-demand module separation (counterclockwise) at stenotic sites. The platform is compatible with intraoperative ultrasound, allowing real-time navigation and thermally triggered expansion in physiological environments. By synergizing programmable magnetic actuation, ultrasound-mediated expansion, and clinical workflow compatibility, the robot can navigate tortuous phantom ducts, achieving controlled stent deployment within 3 seconds and complete expansion within 30 seconds, permitting minimally invasive treatment of biliary strictures. This work advances microrobotic stent delivery by overcoming key barriers to clinical translation in endoluminal interventions.

Science AdvancesVol. 11(43)
Shenzhen Institute of Information Technology (CN), Chinese University of Hong Kong (HK), Harbin Institute of Technology (CN)
Openalex Percentile: Top 17%
Micro and Nano Robotics
1.26
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