Three Previously Undescribed Compounds Isolated From the Leaves of <i>Syzygium antisepticum</i> With Their α‐Glucosidase and Nitric Oxide Inhibitory Activity
Three previously undescribed compounds, 2α,3β,20α,23-tetrahydroxy-nor-30-urs-12-en-28-oic acid 28-O-β-d-glucopyranoside (1), 2α,3β,6β,23-tetrahydroxyoleana-11,13(18)-dien-28-oic acid (2), and 4,6-dihydroxy-3-methyl-2-O-β-d-glucopyranosylbenzophenone (3), together with 11 known compounds (4-14) are isolated from the leaves of Syzygium antisepticum. The isolated compounds are characterized via HR-ESI-MS and NMR spectra. Compounds 1, 2, 6, and 7 exhibited significant inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells with IC<sub>50</sub> values of 16.3, 14.9, 25.5, and 24.7 µM, respectively. In addition, compounds 9-12 displayed the most potential α-glucosidase with IC<sub>50</sub> values ranging from 23.6 to 162.0 µM.
Authors
- Ngo Anh Bang
- Phan Văn Kiệm (ORCID: https://orcid.org/0000-0003-0756-6990)
- Bùi Hữu Tài (ORCID: https://orcid.org/0000-0002-2034-3786)
- Đỗ Thị Trang (ORCID: https://orcid.org/0000-0002-8378-1038)
- Vu Kim Thu
- Lê Thị Thúy Hằng (ORCID: https://orcid.org/0000-0002-9802-2552)
- Nguyêñ Viêt Dũng (ORCID: https://orcid.org/0000-0001-8777-5412)
- Phạm Hải Yến
Institutions
- Hanoi University of Mining and Geology (VN)
- Hanoi University of Natural Resources and Environment (VN)
- Institute of Mathematics (VN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1002/cbdv.202501820
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00