Comprehensive phosphoproteomic profiling reveals sex-specific regulatory mechanisms in HrasG12V-driven hepatocarcinogenesis
This study establishes the first sexual dimorphism-aware phosphoproteomic resource for Ras-driven hepatocarcinogenesis, systematically characterizing conserved and sex-divergent phosphorylation networks. The findings provide preliminary molecular insights into gender disparities in HCC progression and may guide future therapeutic exploration.
Authors
- Dong Xiao-ying
- Yang Yu (ORCID: https://orcid.org/0000-0002-4310-1966)
- Changcheng Yang (ORCID: https://orcid.org/0000-0001-9966-0129)
- Juefu Hu
- Huiling Li (ORCID: https://orcid.org/0000-0002-1724-2087)
- Jun Chen (ORCID: https://orcid.org/0000-0003-2447-0544)
- Aiguo Wang (ORCID: https://orcid.org/0000-0001-5022-3585)
- Liang Yao
Institutions
- Dalian Medical University (CN)
- Hubei University of Chinese Medicine (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1186/s12935-025-04015-2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China