Quantification and material modelling of the localized non-bone regions in the trabecular architecture of the sacrum
Simulating fractures using CT-based bone models enables personalized treatment. However, most commercially-available applications only use bone mineral density (BMD) to calculate Young's modulus, solely considering the mineralized phase. Our methodology maps sacral region material properties by: (1) segmenting bone into mineralized / non-mineralized volumes, (2) calculating mineralized region Young's modulus via BMD approach and non-mineralized region modulus via volume fraction, and (3) generating a FE mesh with material mapping. This enables stress field analysis and Young's modulus approximation for low Hounsfield values. Considering the internal composition of bone is crucial for improving patient-specific FE models and assessing pelvic fractures.
Authors
- Thomas Mendel (ORCID: https://orcid.org/0000-0002-5212-5898)
- Friederike Klauke (ORCID: https://orcid.org/0000-0003-4875-7996)
- Anantha Narayanan Ramakrishnan (ORCID: https://orcid.org/0000-0001-5270-450X)
- Christopher Ludtka (ORCID: https://orcid.org/0000-0002-9080-1594)
- Amadeus C. S. de Alcântara (ORCID: https://orcid.org/0000-0003-4493-0827)
- Stefan Schwan (ORCID: https://orcid.org/0000-0001-9835-7822)
- Munir S. Skaf (ORCID: https://orcid.org/0000-0001-7485-1228)
- Immanuel Ries
Institutions
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Luther University (KR)
- Merseburg University of Applied Sciences (DE)
- University of Florida (US)
- Fraunhofer Institute for Microstructure of Materials and Systems (DE)
- BG Klinikum Bergmannstrost Halle (DE)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Computer Methods in Biomechanics & Biomedical Engineering
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1080/10255842.2025.2575262
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00