CER1 as a manganese ion metabolism gene drives gastric cancer progression and therapeutic potential via oxidative stress and tumor microenvironment regulation
The in-depth investigation of CER1 within the MIM family has markedly deepened our understanding of the complex molecular mechanisms underlying GC. Through targeted manipulation of the NRF2/KEAP1 oxidative stress pathway and T cell function, CER1 emerges as a strategic pathway for potentially inhibiting tumor growth. This investigation outlines a strategic framework to facilitate the advancement of innovative treatment modalities.
Authors
- R. Zhu (ORCID: https://orcid.org/0009-0005-9011-8559)
- Qiushi Huang (ORCID: https://orcid.org/0000-0002-4456-1681)
- Xiaosong Li (ORCID: https://orcid.org/0000-0001-5533-7995)
- Juan Hu (ORCID: https://orcid.org/0000-0002-7530-5525)
Institutions
- Suizhou Central Hospital (CN)
- Ningxia Hui Autonomous Region Peoples Hospital (CN)
- Chongqing Institute of Green and Intelligent Technology (CN)
- Ningxia Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1007/s12672-025-03502-2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00