Correlation of plasma lipidomic profiles with cardiometabolic disease in transfusion-dependent thalassemia patients with six-month N-acetylcysteine intervention: A prospective cohort study
Six-month oral NAC intervention modified the plasma lipidomic profile in TDT patients, partially restoring lipid species likely disrupted by chronic oxidative stress. The observed correlation between NAC-responsive lipids and improved HRV suggests a potential cardioprotective effect. These findings highlight the potential of NAC as an adjunctive therapy to mitigate cardiometabolic complications in TDT.
Authors
- Caroline Daneault (ORCID: https://orcid.org/0000-0002-9839-7506)
- Christine Des Rosiers (ORCID: https://orcid.org/0000-0003-2449-8440)
- Kostas Pantopoulos (ORCID: https://orcid.org/0000-0002-2305-0057)
- Nipon Chattipakorn (ORCID: https://orcid.org/0000-0003-3026-718X)
- Anik Forest
- Yubin Lei (ORCID: https://orcid.org/0000-0002-4468-8076)
- Gary Sweeney (ORCID: https://orcid.org/0000-0002-1946-1347)
- Arintaya Phrommintikul (ORCID: https://orcid.org/0000-0003-3986-1951)
- Siriporn C. Chattipakorn (ORCID: https://orcid.org/0000-0003-1677-7052)
- Adisak Tantiworawit (ORCID: https://orcid.org/0000-0002-2381-9292)
- Ying Liu (ORCID: https://orcid.org/0000-0001-7710-0809)
Institutions
- York University (CA)
- Montreal Heart Institute (CA)
- Jewish General Hospital (CA)
- Chiang Mai University (TH)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Clinical Biochemistry
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1016/j.clinbiochem.2025.111030
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00