Histological characteristics of primary biliary cholangitis in patients with incomplete responses to ursodeoxycholic acid
Liver histology in patients with incomplete responses to UDCA is characterized predominantly by advanced disease features, including severe hepatitis, bile duct loss, and orcein-positive granule deposition, rather than by fibrosis alone. The Nakanuma classification offers a more accurate evaluation of disease severity compared to conventional classifications. These histological findings provide valuable insights for interpreting the outcomes of recent clinical trials of second-line therapies for PBC, particularly those targeting immune-mediated mechanisms.
Authors
- Seiichiro Hojo
- Yasuni Nakanuma (ORCID: https://orcid.org/0000-0003-4117-6611)
- Kenichi Harada (ORCID: https://orcid.org/0000-0002-6451-0638)
- Shinji Shimoda
- Hirohito Tsubouchi (ORCID: https://orcid.org/0000-0002-3585-6787)
- Hitoshi Yoshiji (ORCID: https://orcid.org/0000-0002-5243-8544)
- Yuko Kakuda
- Toshio Imai (ORCID: https://orcid.org/0000-0002-4022-1962)
- Masanori Abe (ORCID: https://orcid.org/0000-0002-5641-4996)
- Hiromasa Ohira (ORCID: https://orcid.org/0000-0003-4331-0634)
- Mikio Zeniya (ORCID: https://orcid.org/0000-0001-7695-2444)
- Tadashi Namisaki (ORCID: https://orcid.org/0000-0002-3158-5318)
- Tetsu Kawano
- Atsushi Tanaka (ORCID: https://orcid.org/0000-0002-6358-5283)
- Atsushi Umeda
- Yukari Higashine
- Yuki Kamiya
- Akio Ido
Institutions
- Kanazawa University (JP)
- Kagoshima University (JP)
- Kansai Medical University (JP)
- Fukushima Medical University (JP)
- Kobe Institute Of Computing (JP)
- Shizuoka Cancer Center (JP)
- KAN Research Institute (JP)
- Kagoshima City Hospital (JP)
- Fukui-ken Saiseikai Hospital (JP)
- EA Pharma (Japan) (JP)
- Ehime University (JP)
- Eisai (Japan) (JP)
- Nara Medical University (JP)
- International University of Health and Welfare (JP)
- Teikyo University (JP)
Publication Details
- Journal
- Human Pathology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1016/j.humpath.2025.105957
- Citations
- 1
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 1.32