Association Between the Genetic Risk for Attention-Deficit/Hyperactivity Disorder and Cognitive Function in Older Age: The MYHAT Population-Based Study
Overall, ADHD genetic liability appears relevant to cognitive performance in late life, though longitudinal trajectories remain unaffected. In older age, ADHD-PRS seems to negatively impact visuospatial tests, characterized by complex and integrative demands. Educational attainment moderated the associations with attention and language, suggesting a potential buffering effect.
Authors
- Mary Ganguli
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Chung-Chou H. Chang (ORCID: https://orcid.org/0000-0001-8719-2508)
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Kang-Hsien Fan (ORCID: https://orcid.org/0000-0003-0121-3959)
- Erin Jacobsen (ORCID: https://orcid.org/0000-0002-4599-6214)
- Yingjin Zhang (ORCID: https://orcid.org/0000-0001-9296-6440)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- Beth E. Snitz (ORCID: https://orcid.org/0000-0002-9978-1374)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Esther Teverovsky (ORCID: https://orcid.org/0000-0002-1340-7649)
- Brooke S. G. Molina (ORCID: https://orcid.org/0000-0001-7574-3755)
- M. Ilyas Kamboh (ORCID: https://orcid.org/0000-0002-3453-1438)
- Yueting Wang (ORCID: https://orcid.org/0000-0003-3775-4044)
Institutions
- University of Pittsburgh (US)
- Department of Health (TW)
Publication Details
- Journal
- American Journal of Geriatric Psychiatry
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jagp.2025.10.005
- Citations
- 1
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- U.S. Department of Health and Human Services
- University of Pennsylvania
- University of Pittsburgh
- Siemens Healthineers
- National Institutes of Health
- National Institute on Aging
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke