Overall side‐effect bother consistently associated with early treatment discontinuation due to adverse events in four clinical trials with various cancer types and treatments
These results support prior research demonstrating an association between severe side-effect bother, as reported on responses to the GP5 item, and ETD among patients with newly diagnosed multiple myeloma. The consistent association between GP5 responses and ETD suggests the GP5's ability to capture how well patients tolerate treatment, especially when side-effect bother is observed early in the course of treatment, and signals an opportunity to develop interventions to promote treatment adherence.
Authors
- Jessica Roydhouse (ORCID: https://orcid.org/0000-0002-8025-5841)
- Nathaniel S. O’Connell (ORCID: https://orcid.org/0000-0002-3827-5152)
- Ahmad A. Tarhini (ORCID: https://orcid.org/0000-0002-3193-9702)
- Edward H. Ip (ORCID: https://orcid.org/0000-0002-4811-4205)
- Mary Lou Smith (ORCID: https://orcid.org/0000-0002-1937-1026)
- Tait D. Shanafelt (ORCID: https://orcid.org/0000-0002-7106-5202)
- Fengmin Zhao (ORCID: https://orcid.org/0000-0001-9826-3703)
- David F Cella (ORCID: https://orcid.org/0000-0002-9881-4541)
- John Devin Peipert (ORCID: https://orcid.org/0000-0001-5762-7881)
- Ju‐Whei Lee (ORCID: https://orcid.org/0000-0003-2068-8511)
- Ruth C. Carlos (ORCID: https://orcid.org/0000-0001-7055-7662)
- Robert J. Gray (ORCID: https://orcid.org/0000-0002-5724-4917)
- Lynne I. Wagner (ORCID: https://orcid.org/0000-0001-9685-4796)
- Noah Graham (ORCID: https://orcid.org/0009-0009-0622-683X)
- Ilana F. Gareen (ORCID: https://orcid.org/0000-0002-0457-5595)
- Pamela J. Raper
- Vered Stearns
- Shaili Ganatra
Institutions
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- University of Tasmania (AU)
- Rhode Island Department of Health (US)
- Cornell University (US)
- Brown University (US)
- Moffitt Cancer Center (US)
- Eastern Cooperative Oncology Group (US)
- Stanford Medicine (US)
- Research Advocacy Network (US)
- Weill Cornell Medicine (US)
- Wake Forest University (US)
- Columbia University (US)
- University of Birmingham (GB)
- Stanford University (US)
Publication Details
- Journal
- Cancer
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1002/cncr.70084
- Citations
- 2
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 5.26
Funders
- National Institutes of Health
- National Cancer Institute