Alpha-1 antitrypsin Pi*MZ variant increases the risk of liver disease progression in MASLD and MASH
Carriage of the Pi*Z mutation significantly affects the risk of future clinical outcomes among individuals with MASLD/MASH. The MZ genotype confers a risk equivalent to established RFs in MASLD/MASH, underscoring the importance of screening and further work to understand the underlying mechanisms.
Authors
- Pavel Strnad (ORCID: https://orcid.org/0000-0002-7122-6379)
- Rohit Seth Loomba (ORCID: https://orcid.org/0000-0002-4845-9991)
- Bradley Jermy
- Jack Brownrigg
Institutions
- University of California San Diego (US)
- BioMarin (United Kingdom) (GB)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Annals of Hepatology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1016/j.aohep.2025.102143
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35