Therapeutic potential of miRNA-26a-encapsulated nanoparticles against hepatocellular carcinoma in a murine model
Administration of miRNA-26a-encapsulated nanoparticles induced nearly total regression of HCC, suppression of cancer cell growth and angiogenesis, and induction of tumor necrosis. This study demonstrates the therapeutic efficacy of restoring the imbalanced expression of miRNA in the liver. Therefore, the clinical translation of this miRNA-based strategy warrants further investigation.
Authors
- Tarek Aboushousha (ORCID: https://orcid.org/0000-0002-6686-2442)
- Ehab Hafiz (ORCID: https://orcid.org/0000-0002-1551-4309)
- Iker Badiola (ORCID: https://orcid.org/0000-0003-2392-2537)
- I. Fernandez-Piñeiro
- Eman El‐Ahwany (ORCID: https://orcid.org/0000-0003-4871-5892)
- Marwa Hassan (ORCID: https://orcid.org/0000-0001-9751-8129)
- Alejandro Sánchez (ORCID: https://orcid.org/0000-0002-1880-0036)
- Mohamed Elzallat
Institutions
- University of the Basque Country (ES)
- Universidade de Santiago de Compostela (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Theodor Bilharz Research Institute (EG)
Publication Details
- Journal
- Liver Research
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1016/j.livres.2025.10.002
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94