T-Cell Receptor Clonotypes and Aggressive Subtypes in Cutaneous T-Cell Lymphoma
This cohort study's analysis of TCRB and TCRG repertoires identified specific clonotypes that were associated with more aggressive subtypes and poorer survival in patients with MF/SS. Incorporating TCR sequencing into clinical practice may enhance risk stratification, enabling earlier identification of high-risk patients who could benefit from closer monitoring and timely implementation of more intensive treatment strategies in the disease course to improve clinical outcomes.
Authors
- Jasmine Zain (ORCID: https://orcid.org/0009-0009-0753-1019)
- Steven T. Rosen (ORCID: https://orcid.org/0000-0002-8818-7724)
- Christiane Querfeld (ORCID: https://orcid.org/0000-0001-9698-5809)
- Liliana Crisan
- Michelle Afkhami (ORCID: https://orcid.org/0000-0001-5830-6158)
- Raju Pillai (ORCID: https://orcid.org/0000-0001-8553-4252)
- Shanpeng Li (ORCID: https://orcid.org/0000-0002-0724-4564)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- City of Hope (US)
Publication Details
- Journal
- JAMA Dermatology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1001/jamadermatol.2025.4081
- Citations
- 3
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 6.01