Gene Expression Profile–Based Test to Predict Melanoma Sentinel Node Status
In this multicenter, prospective, blinded, prognostic study, the CP-GEP test reliably identified patients with melanoma with less than 10% SLN metastasis risk. SLN metastasis rates were approximately 3-fold greater for high-risk vs low-risk CP-GEP cases. In appropriately selected patients, the CP-GEP test may add value for shared patient-surgeon decision-making.
Authors
- John Hyngstrom (ORCID: https://orcid.org/0000-0002-4833-3838)
- Prakash K. Pandalai (ORCID: https://orcid.org/0000-0002-2729-0058)
- Christina Vadala Angeles (ORCID: https://orcid.org/0000-0002-6500-9589)
- Jane L. Messina (ORCID: https://orcid.org/0000-0002-0332-0224)
- Nabil Wasif (ORCID: https://orcid.org/0000-0001-7979-6766)
- Jonathan S. Zager (ORCID: https://orcid.org/0000-0002-6886-4468)
- Keith A. Delman (ORCID: https://orcid.org/0000-0003-2387-0378)
- Klaus J. Busam (ORCID: https://orcid.org/0000-0003-0888-9601)
- Michael Lowe (ORCID: https://orcid.org/0000-0003-4853-7352)
- Edmund K. Bartlett (ORCID: https://orcid.org/0000-0002-0923-153X)
- Julia Scott Lehman (ORCID: https://orcid.org/0000-0002-7389-3853)
- Georgia M. Beasley (ORCID: https://orcid.org/0000-0001-6387-9030)
- Erin E. Burke (ORCID: https://orcid.org/0000-0002-7559-4961)
- Tina J. Hieken (ORCID: https://orcid.org/0000-0002-4277-8692)
- Michael E. Egger (ORCID: https://orcid.org/0000-0002-8263-751X)
- Sanjay P. Bagaria (ORCID: https://orcid.org/0000-0001-6677-8964)
- Kelly M. McMasters (ORCID: https://orcid.org/0000-0001-9554-3857)
- Jay Lee (ORCID: https://orcid.org/0000-0002-4016-7003)
- Scott C. Bresler (ORCID: https://orcid.org/0000-0002-4093-4196)
- Kelly L. Harms (ORCID: https://orcid.org/0000-0002-1502-7914)
- Vernon K. Sondak
- David A. Wada
Institutions
- Mayo Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Louisville (US)
- University of Kentucky (US)
- Emory University (US)
- Duke University (US)
- Huntsman Cancer Institute (US)
- Jacksonville College (US)
- Moffitt Cancer Center (US)
- Michigan Medicine (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Rush University (US)
- The Ohio State University (US)
Publication Details
- Journal
- JAMA Surgery
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1001/jamasurg.2025.4399
- Citations
- 9
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 9.41