Unraveling the Genetic Links Between Polycystic Kidney Disease and Hypertension Through ARL13B
Our bidirectional MR study demonstrated a causal effect of PKD on hypertension and a reverse influence of hypertension on PKD progression. Elevated ARL13B expression in ADPKD suggested a possible involvement of cilia-related pathways in the development of renal hypertension.
Authors
- Chenchen Zhou (ORCID: https://orcid.org/0000-0002-6427-5869)
- Juan Chen
- Jing Huang (ORCID: https://orcid.org/0000-0002-0481-8702)
- Shuqin Mei (ORCID: https://orcid.org/0000-0002-7402-6399)
- Cheng Xue (ORCID: https://orcid.org/0000-0002-4132-9406)
- Zhiguo Mao (ORCID: https://orcid.org/0000-0003-2759-1421)
- Liming Zhang (ORCID: https://orcid.org/0000-0002-0990-7042)
- Xiaohua Hu (ORCID: https://orcid.org/0000-0002-2161-1324)
- Lili Fu (ORCID: https://orcid.org/0009-0009-0062-7931)
- Lei Song
Institutions
- Second Military Medical University (CN)
- Augusta University (US)
- Shanghai Changzheng Hospital (CN)
- People's Hospital of Yangzhong (CN)
Publication Details
- Journal
- International Journal of Nephrology and Renovascular Disease
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/ijnrd.s550416
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- China Scholarship Council