A Randomized Trial Testing a Novel Mind and Body Intervention for Depression: Cognitive Behavioral Therapy (CBT) and Whole-Body Hyperthermia (WBH)
Study procedures were acceptable. Participants in the WBH and sham WBH groups had substantial reductions in depressive symptoms that were greater than typically seen with CBT alone. The sham WBH arm was not fully credible and may have exerted antidepressant effects, thus raising concerns about its use in future trials. Further research to test whether adding WBH to CBT results in additional antidepressant effects is warranted.
Authors
- E Hartley
- Chelsea J. Siwik (ORCID: https://orcid.org/0000-0003-1417-8582)
- Rhonda P. Patrick
- Christopher A. Lowry (ORCID: https://orcid.org/0000-0003-3920-5575)
- Charles L. Raison (ORCID: https://orcid.org/0000-0001-6687-0066)
- Stefanie Roberts (ORCID: https://orcid.org/0000-0001-8969-7577)
- Erika Jung
- Wendy Hartogensis (ORCID: https://orcid.org/0000-0002-4979-8661)
- Ashley E. Mason (ORCID: https://orcid.org/0000-0002-8744-0185)
- Frederick Hecht (ORCID: https://orcid.org/0000-0002-5782-1171)
- Lindsey B. Hopkins (ORCID: https://orcid.org/0000-0002-0577-2961)
- Patricia J. Moran (ORCID: https://orcid.org/0000-0003-2422-3471)
- Osnat Lupesko-Persky
- Anoushka Chowdhary (ORCID: https://orcid.org/0000-0002-5552-6507)
- Leena S. Pandya (ORCID: https://orcid.org/0000-0001-7033-6800)
- J. Craig Nelson
- Jenna Borovinsky
Institutions
- Cleveland Clinic (US)
- University of Wisconsin–Madison (US)
- University of Arizona (US)
- University of California, San Francisco (US)
- University of Colorado Boulder (US)
- University of Colorado System (US)
- Center for Innovation (US)
Publication Details
- Journal
- Global Advances in Integrative Medicine and Health
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1177/27536130251387714
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 0.00