Antibody-mediated rejection in ABO-incompatible kidney transplantation
ABOi transplantation reduces the risk of developing de novo anti-HLA DSA. Banff 2022 criteria may over-diagnose AMR. Biopsy-based transcript diagnostics differentiate anti-HLA- and anti-A/B-mediated alloimmune injury from C4d deposition due to accommodation. Interestingly, C4d deposition drives molecular AMR activity in ABOc biopsies.
Authors
- Thomas Schachtner (ORCID: https://orcid.org/0000-0001-5549-4798)
- Britta George (ORCID: https://orcid.org/0000-0001-5430-5086)
- Kerstin Huebel (ORCID: https://orcid.org/0000-0002-0633-7689)
- Elena Rho (ORCID: https://orcid.org/0000-0003-0687-3753)
- Lukas Weidmann (ORCID: https://orcid.org/0009-0001-4948-0995)
- Fabian Rössler (ORCID: https://orcid.org/0000-0002-2968-347X)
- Dušan Harmáček (ORCID: https://orcid.org/0000-0001-7863-9072)
- Seraina von Moos (ORCID: https://orcid.org/0000-0002-1050-2800)
- Kai Castrezana Lopez
Institutions
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1093/ndt/gfaf224
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Baugarten Stiftung