#2526 Anemia as a predictor of peritoneal dialysis withdrawal in stable peritoneal dialysis patients

Abstract Background and Aims Anemia is recognized as a risk factor for early withdrawal of peritoneal dialysis (PD). However, its impact on patients with stable PD has not yet been fully elucidated. This study aimed to explore the association between anemia and PD withdrawal in patients with stable PD. Method A total of 43 patients who underwent PD for at least 6 months were included in this study. Patients were categorized into two groups based on hemoglobin (Hb) levels: those with Hb ≥11 g/dL (22 patients) and those with Hb <11 g/dL (21 patients). The subsequent PD withdrawal rates were compared between the groups. Additionally, the relationship between Hb levels and subsequent annual decline in urinary volume was examined. Results The median PD duration was 14 months, and 37 patients transitioned from PD during a mean follow-up of 37.5 months. The PD withdrawal rate was significantly higher in the Hb level <11 g/dL group (log-rank test, P = 0.02). Moreover, in a Cox proportional hazards model adjusted for patient background, Hb level remained a significant predictor of PD withdrawal (hazard ratio [HR], 0.73; 95% CI: 0.54–0.99, P = 0.04). Furthermore, Hb levels were inversely correlated with the subsequent annual rate of urinary volume decline (r = −0.34, P = 0.02). Multivariable analysis also showed that Hb levels were independently correlated with the subsequent annual rate of urinary volume decline (standard β = −0.35, P = 0.03). Conclusion These findings suggest that anemia is a risk factor for PD withdrawal in stable PD patients, potentially due to its association with a decline in residual renal function.