Comparison of Esketamine and Propofol for Prehospital Emergency Anaesthesia in Patients With Traumatic Brain Injury—A Retrospective Observational Study

Patients with severe head injuries can receive advance intensive care including anaesthetic drugs in the field for intubation, when prehospital teams have this competence. This retrospective analysis presents a comparison of outcomes for traumatic brain injury cases who received either propofol or esketamine in the prehospital setting, as part of a time-interrupted series where drug choice was changed. While possibly differing in circulatory effects, the two drugs were not associated with a difference in mortality before hospital discharge.