Psychological Science at the Cellular Level: Mitochondria’s Role in Health and Behavior

The biopsychosocial model (BPSM) has guided psychological science for decades by emphasizing the interplay of biological, psychological, and social factors in health. Despite its influence, the model has been critiqued for lacking mechanistic specificity, particularly in clarifying how psychosocial factors translate into cellular and molecular processes. Mitochondria, once viewed mainly as energy producers, are now understood to shape immune signaling, stress responses, and neural functioning. Emerging evidence shows that mitochondrial processes are sensitive to psychosocial influences such as chronic stress, trauma, and social connection, with downstream effects on inflammation and disease risk. We highlight findings that support these links while noting areas in which evidence remains preliminary, including possible feedback from mitochondrial changes to psychosocial processes. We also review interventions such as physical activity, mindfulness, and social support that may enhance mitochondrial function. This article positions mitochondria as one promising biological bridge between mind and body, offering a testable extension of the BPSM and identifying opportunities for psychologists to advance this emerging field.