#131 Predictors and prevalence of hypomagnesemia in critically ill non oliguric acute kidney injury patients

Abstract Background and Aims Hypomagnesemia is common in critically ill patient and magnesium levels play pivotal role in homeostasis. Fraction excretion of magnesium which is a surrogate of magnesium wasting in critical care patients. Data regarding association and prevalence of hypomagnesemia in non oliguric AKI patients is scarce. Current study aims to study prevalence of hypomagnesemia and associated risk factors in non-oliguric AKI patients. Method It is a prospective observational single center non-randomized trial. Total of 52 non oliguric AKI (KDIGO Stage 2 and stage 3) patients admitted in Intensive care were studied over the duration of 2 years. Serum magnesium and fraction excretion of magnesium were monitored on day 1, day 3 and day 7 of hospital admission. Various risk factors that may be associated with hypomagnesemia were also studied. Results Out of 52 admitted patients in ICU, 3 patients required ventilatory support. 38 out of 52 (73.1%) had hypomagnesemia within 7 days of admission. FeMg (Fraction excretion of magnesium) was high in all non-oliguric AKI patients. Mean FeMg was 6.83% + 2.26 on Day 1 which rose to 8.19% + 2.77 on day 3 and decreased slightly to 6.77% + 2.52 on Day 7. None of the predictors, including ICU stay duration, age, sex, ventilatory support, history of diabetes or hypertension, alcoholism, urine output, vasopressor need and neuromuscular changes show statistically significant associations with hypomagnesemia (P > .05). Conclusion Magnesiuria and hypomagnesemia is common in non-oliguric AKI patients in critical care settings. Early monitoring is required which may prevent morbidity. More studies are required to assess risk factors and to address mitigation strategies.