Ssrp governs germline development independent of the FACT complex in Drosophila spermatogenesis
This work reveals previously unknown, context-dependent functions of Ssrp during Drosophila spermatogenesis. Ssrp emerges as a multifunctional orchestrator essential for both somatic and germline compartments of germline development. These findings provide crucial foundational insights into reproductive disorders associated with Ssrp dysfunction and underscore the importance of the FACT complex in male germ cell development.
Authors
- Jianping Jin (ORCID: https://orcid.org/0000-0003-2722-0591)
- Xiaohang Yang (ORCID: https://orcid.org/0000-0001-5192-5706)
- Xiang‐Mei Tan (ORCID: https://orcid.org/0000-0001-8446-8783)
- Yuhan Lou
- Jiaqi Zhao (ORCID: https://orcid.org/0000-0002-3301-1916)
- Yongmei Xi (ORCID: https://orcid.org/0000-0001-7374-2564)
- Huimei Zheng (ORCID: https://orcid.org/0000-0001-7129-8412)
- Zhiyong Yin (ORCID: https://orcid.org/0009-0004-7316-496X)
- Yunbo Wang
- Jia Wang (ORCID: https://orcid.org/0000-0002-2330-8505)
Institutions
- Zhejiang International Studies University (CN)
- Baylor College of Medicine (US)
- Jinan Maternity And Care Hospital (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Shandong First Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1186/s13578-025-01478-8
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Zhejiang University