White matter lesion effect modification of aspirin and unfractionated heparin during endovascular stroke treatment
Periprocedural aspirin and unfractionated heparin during endovascular treatment cause a higher hemorrhage risk. WML volume is associated with worse functional outcome and WML volume significantly modifies the effect of aspirin on symptomatic hemorrhage risk, with aspirin-associated risk decreasing with increasing WML volume. No WML-volume-based patient subgroup was identified where aspirin or heparin treatment demonstrated safe clinical benefit.
Authors
- Praneeta R. Konduri (ORCID: https://orcid.org/0000-0002-9911-2090)
- Laura M. van Poppel (ORCID: https://orcid.org/0000-0001-7921-2353)
- Bart J. Emmer (ORCID: https://orcid.org/0000-0001-8462-4037)
- Henk A. Marquering (ORCID: https://orcid.org/0000-0002-1414-6313)
- Charles B.L.M. Majoie (ORCID: https://orcid.org/0000-0002-7600-9568)
- Rob A. van de Graaf (ORCID: https://orcid.org/0000-0003-4459-0068)
- Mahsa Mojtahedi (ORCID: https://orcid.org/0000-0003-1860-1114)
- Henk van Voorst (ORCID: https://orcid.org/0000-0002-2647-3557)
- Wouter van der Steen (ORCID: https://orcid.org/0000-0001-9428-1920)
- Laura Martou (ORCID: https://orcid.org/0000-0001-8872-0085)
- Lucas de Vries (ORCID: https://orcid.org/0000-0002-8117-9158)
- Paul Bentley (ORCID: https://orcid.org/0000-0001-8036-7010)
Institutions
- Erasmus MC (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Imperial College London (GB)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
- Stanford University (US)
Publication Details
- Journal
- Insights into Imaging
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1186/s13244-025-02095-2
- Citations
- 1
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Stryker
- National Institute for Health and Care Research
- Imperial College London
- European Commission