Loss of miR-122 promotes cell migration and poor prognosis in triple-negative breast cancer treated by neoadjuvant chemotherapy
The loss of miR-122 in TNBC tumors is associated with rapid relapse after chemotherapy in patients and allows cell migration by promoting a metastatic-related transcriptomic landscape, including positive modulation of BORIS expression.
Authors
- Claudia Haydée González-De la Rosa (ORCID: https://orcid.org/0000-0002-1878-6967)
- Nicolás Villegas‐Sepúlveda (ORCID: https://orcid.org/0000-0001-9489-2545)
- Isidro X. Perez‐Añorve
- Ernesto Soto‐Reyes (ORCID: https://orcid.org/0000-0002-4219-6406)
- Joaquín Manzo-Merino (ORCID: https://orcid.org/0000-0003-1672-6626)
- Mauricio Flores‐Fortis (ORCID: https://orcid.org/0000-0002-3227-3666)
- Arturo Aguilar‐Rojas
- Carlos César Patiño-Morales (ORCID: https://orcid.org/0000-0003-1995-0308)
- Elena Aréchaga-Ocampo (ORCID: https://orcid.org/0000-0002-0787-5593)
Institutions
- Universidad Autónoma Metropolitana (MX)
- Hospital Infantil de México Federico Gómez (MX)
- Hospital de Especialidades (MX)
- Centro de Investigación en Materiales Avanzados (MX)
- Instituto Nacional de Cancerología (MX)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1007/s12094-025-04082-x
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00