The CT-based attenuation index of peri-bowel adipose tissue can predict disease progression in inflammatory bowel disease patients
Questions The peri-bowel fat attenuation index (FAI) helps detect peri-bowel fat inflammation noninvasively, but its importance for risk stratification and prediction of clinical outcomes remains unknown. Findings The peri-bowel FAI was an independent predictor of inflammatory bowel disease (IBD) disease progression with an optimum cutoff of 25.1 HU. Clinical relevance The peri-bowel FAI is a promising biomarker for contributing to the identification of so-called high-risk patients with uncontrolled inflammation, who might be candidates for more intensive treatment for addressing underlying inflammation at early stages and ultimately improve long-term prognosis.
Authors
- Jun Lü (ORCID: https://orcid.org/0000-0003-1625-8682)
- Jing Zheng (ORCID: https://orcid.org/0000-0002-8510-0275)
- Xuxu Meng
- Zhenghan Yang (ORCID: https://orcid.org/0000-0003-3986-1732)
- Lixue Xu (ORCID: https://orcid.org/0000-0002-7152-2741)
- Zhenchang Wang (ORCID: https://orcid.org/0000-0001-8190-6469)
- Yuxin Wang (ORCID: https://orcid.org/0000-0003-3559-2192)
- Xiaoyang Li (ORCID: https://orcid.org/0000-0003-3684-2106)
- Jingxuan Zhang (ORCID: https://orcid.org/0000-0002-8105-1023)
- Tianxin Cheng (ORCID: https://orcid.org/0009-0009-0503-7877)
- Jiahui Jiang (ORCID: https://orcid.org/0000-0002-8645-4008)
- Xue Dong (ORCID: https://orcid.org/0000-0001-8114-4046)
- Xinjun Han (ORCID: https://orcid.org/0000-0001-9908-6374)
- Hui Xu
Institutions
- Capital Medical University (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- European Radiology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1007/s00330-025-12079-x
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00