DENR reduces cisplatin sensitivity in esophageal squamous cell carcinoma via ATF4-Mediated ferroptosis inhibition
DENR promotes cisplatin resistance in ESCC by inhibiting ferroptosis through an ATF4-dependent mechanism. Targeting the DENR/ATF4 axis may represent a promising strategy to overcome chemoresistance in ESCC.
Authors
- Xiaoqing Ge (ORCID: https://orcid.org/0000-0001-9152-6929)
- Lu Hou (ORCID: https://orcid.org/0009-0005-7559-7256)
- Yang Chen (ORCID: https://orcid.org/0000-0003-2641-6146)
- Xianen Fa (ORCID: https://orcid.org/0000-0002-8702-2178)
- Chong Zhao
Institutions
- Second Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1016/j.bbrc.2025.152839
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00