Design, synthesis and anticancer evaluation of some benzothiazole- sulphonamide hybrids

A novel series of sulphonamido-benzothiazole ( 12a-j ) derivatives were designed and synthesized. All compounds were determined by (Sireesha et al., 2023 1) HNMR, Bandaru et al. (2022) 13 CNMR and mass spectral analysis. Further, all compounds were screened for their anticancer activities against a panel of human cancer cell lines like breast (MCF-7, MDA MB-231), lung (A549) and prostate (DU-145) human cancer cell lines by using the MTT assay, and etoposide was used as a reference drug. Most of the compounds showed moderate to good anticancer activity on cell lines and were compared to the clinical drug as etoposide. The compounds that showed IC 50 values ranging from 0.012 ± 0.0044 μM to 12.7 ± 5.38 μM, and the etoposide exhibited 1.91 ± 0.84 μM to 3.08 ± 0.135 μM. Among the developed compounds, six compounds 20a, 20b, 20c, 20 g, 20i and 20j displayed significant anticancer activities on cell lines to compare with etoposide. • A novel series of sulphonamido-benzothiazole ( 12a-j ) derivatives were designed and synthesized. All compounds were determined by (Sireesha et al., 2023 1) HNMR, Bandaru et al. (2022) 13 CNMR and mass spectral analysis. • all compounds were screened for their anticancer activities against a panel of human cancer cell lines like breast (MCF-7, MDA MB-231), lung (A549) and prostate (DU-145) human cancer cell lines • Among the developed compounds, six compounds 20a, 20b, 20c, 20 g, 20i and 20j displayed significant anticancer activities on cell lines to compare with etoposide. • The compounds showed IC 50 values ranging from 0.012 ± 0.0044 μM to 12.7 ± 5.38 μM, and the etoposide exhibited 1.91 ± 0.84 μM to 3.08 ± 0.135 μM.