Genotype-dependent cell tropism of EV-A71 at the human blood cerebrospinal fluid and blood brain barrier
Our findings reveal that different genotypes of EV-A71 exhibit distinct tropisms at the level of the brain barriers, which may correlate with variations in the clinical course of infection. Clinical and molecular surveillance of EV infections beyond those currently established in the Asia-Pacific region is warranted.
Authors
- Christel Weiß (ORCID: https://orcid.org/0000-0002-8692-5690)
- Tobias Tenenbaum (ORCID: https://orcid.org/0000-0002-7215-8398)
- A Hügel
- Carolin Stump-Guthier
- Horst Schroten (ORCID: https://orcid.org/0009-0001-6779-1084)
- Sabine Diedrich (ORCID: https://orcid.org/0000-0002-3454-2647)
- Ortwin Adams (ORCID: https://orcid.org/0000-0002-9194-8475)
- Christian Schwerk (ORCID: https://orcid.org/0000-0002-1706-0259)
- Hiroshi Ishikawa (ORCID: https://orcid.org/0000-0001-6310-5748)
- Henriette Rudolph (ORCID: https://orcid.org/0000-0002-3809-4861)
- Sindy Boettcher (ORCID: https://orcid.org/0000-0002-3454-2647)
Institutions
- Goethe University Frankfurt (DE)
- University of Tsukuba (JP)
- University of Mannheim (DE)
- Heidelberg University (DE)
- Robert Koch Institute (DE)
- University Hospital Heidelberg (DE)
- University Hospital Frankfurt (DE)
- University Medical Centre Mannheim (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Microbial Pathogenesis
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1016/j.micpath.2025.108129
- Citations
- 1
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39