Decoding oral leukoplakia: microbiome dysbiosis and inflammatory dynamics unveiled in a rat model
This study demonstrates the utility of 2bRAD-M sequencing in overcoming traditional metagenomic limitations, offering a high-resolution view of microbiome dynamics in low-biomass environments such as the oral mucosa. These findings establish the oral microbiota as candidate early biomarkers for OLK screening and prevention, opening avenues for precision diagnostics and targeted therapies to mitigate cancer risk associated with OLK.
Authors
- Zhenjiang Zech Xu (ORCID: https://orcid.org/0000-0003-1080-024X)
- Tingting Zhu (ORCID: https://orcid.org/0000-0002-0904-7636)
- Jia-Zhen Yang (ORCID: https://orcid.org/0000-0003-2201-3059)
- Shi Huang (ORCID: https://orcid.org/0000-0002-7529-2269)
- Yufeng Zhang (ORCID: https://orcid.org/0000-0002-3347-1058)
- Enoch Kao
- Wanchun Wang
- Fei Teng (ORCID: https://orcid.org/0009-0006-7948-2613)
- Zhiqin Sang
Institutions
- Qingdao University (CN)
- Nanchang University (CN)
- Chinese University of Hong Kong (HK)
- State Key Laboratory of Food Science and Technology (CN)
- Ocean University of China (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fmicb.2025.1613165
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qingdao Key Health Discipline Development Fund
- Natural Science Foundation of Shandong Province
- Qingdao University
- Health and Medical Research Fund