Sodium glucose co-transporter 2 inhibitor empagliflozin prevents endothelial dysfunction induced by oscillatory shear stress
EMPA prevents OSS induced ROS generation by the inhibition of the NHE1/NCX/Ca<sup>2+</sup> axis. The suppression of OSS-induced ROS generation by EMPA contributes to improved endothelial barrier function of endothelial cells but has limited effect on the inflammatory response in HCAECs subjected to OSS.
Authors
- Benedikt Preckel (ORCID: https://orcid.org/0000-0003-4412-9183)
- Nina C. Weber (ORCID: https://orcid.org/0000-0003-1111-9042)
- Martin Albrecht (ORCID: https://orcid.org/0000-0003-2580-768X)
- Coert J. Zuurbier (ORCID: https://orcid.org/0000-0001-8361-2448)
- Marta Z. Pacia (ORCID: https://orcid.org/0000-0002-0391-2502)
- Markus W. Hollmann (ORCID: https://orcid.org/0000-0001-8248-0244)
- Xiaoling Li
- Mengnan Wang (ORCID: https://orcid.org/0000-0003-0081-6264)
- Yasmeen M. Butt (ORCID: https://orcid.org/0000-0002-9991-2506)
- Jil Seehaber
- Charlotte Stuhldreier
Institutions
- Jagiellonian University (PL)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Amsterdam UMC Location University of Amsterdam (NL)
- University Hospital Schleswig-Holstein (DE)
- Universitäts Hautklinik Kiel (DE)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
- University of Lübeck (DE)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1016/j.biopha.2025.118670
- Citations
- 1
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29