Platelet derived growth factor-AB modulates post-infarct myocardium leading to extended improvement in cardiac function
Myocardial infarction (MI) contributes to significant morbidity and mortality globally. Platelet derived growth factor-AB (PDGF-AB) is potentially a novel translational therapeutic for improving cardiac function post-MI, which we assess here using a 60 day porcine left anterior descending artery occlusion ischemia-reperfusion model. MI was induced in 10 female Landrace swine, with 5 controls, 5 receiving PDGF-AB treatment and 2 additional shams. PDGF-AB improved left ventricular ejection fraction 58 days after MI, without affecting overall infarct scar size, as shown using serial cardiac magnetic resonance imaging. Preserved infarct zone microvascular function and increased vessel maturity was also observed. Multi-omic analyses showed that PDGF-AB treatment altered the expression of proteins, metabolites, and lipids that are known to be involved in myocardial energetics and redox balance. Novel therapeutics such as PDGF-AB may lead to more sustained salvage of cardiac function by modulating the post-MI microvasculature, myocardium and extracellular matrix.
Authors
- Sergey Tumanov (ORCID: https://orcid.org/0000-0002-0557-3153)
- Faraz Pathan (ORCID: https://orcid.org/0000-0002-0939-5470)
- Sindhu Igoor
- Eddy Kizana (ORCID: https://orcid.org/0000-0002-7266-6720)
- James J.H. Chong (ORCID: https://orcid.org/0000-0002-5201-4856)
- Tejas Deshmukh (ORCID: https://orcid.org/0000-0003-0737-7006)
- Tim Campbell
- Sheryl Foster (ORCID: https://orcid.org/0000-0003-3725-0823)
- Juntang Lu (ORCID: https://orcid.org/0000-0002-7438-310X)
- Saurabh Kumar (ORCID: https://orcid.org/0000-0002-4494-4607)
- Samual Turnbull
- Jim Pouliopoulos
- Yasuhito Kotake (ORCID: https://orcid.org/0000-0003-4690-8885)
- Vu Tran (ORCID: https://orcid.org/0000-0003-1663-1168)
- Stuart J. Cordwell (ORCID: https://orcid.org/0000-0002-0995-0171)
- Niv Vigder (ORCID: https://orcid.org/0009-0004-9693-4779)
- Robert D. Hume (ORCID: https://orcid.org/0000-0003-3694-9333)
- Siqi Chen (ORCID: https://orcid.org/0009-0002-5008-7522)
- Christopher Nguyen (ORCID: https://orcid.org/0009-0008-8206-4177)
- Tony Barry
- Andrew Jabbour
Institutions
- Brigham and Women's Hospital (US)
- The University of Sydney (AU)
- Cleveland Clinic (US)
- Harvard University (US)
- Victor Chang Cardiac Research Institute (AU)
- The Heart Research Institute (AU)
- Nepean Hospital (AU)
- Westmead Hospital (AU)
- UNSW Sydney (AU)
- Cleveland Clinic Lerner College of Medicine (US)
- Westmead Institute (AU)
- Westmead Institute for Medical Research (AU)
- Baird Institute (AU)
Publication Details
- Journal
- npj Regenerative Medicine
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1038/s41536-025-00433-y
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Government
- National Heart Foundation of Australia
- Heart Research Institute
- University of New South Wales
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council