Elevated TFEB expression with limited activation in peripheral blood mononuclear cells reflects altered lysosomal enzyme dynamics in Parkinson's disease
Elevated TFEB expression in PBMCs may reflect a compensatory response to PD-related cellular stress. However, this response may be functionally insufficient due to limited TFEB activity, potentially leading to reduced lysosomal enzyme release. Thus, peripheral TFEB-related lysosomal abnormalities may serve as indicators of systemic autophagy-lysosome dysregulation in PD.
Authors
- Hirohisa Watanabe (ORCID: https://orcid.org/0000-0001-8553-8536)
- Reiko Ohdake (ORCID: https://orcid.org/0000-0001-8282-9434)
- Mizuki Ito (ORCID: https://orcid.org/0000-0003-4470-1004)
- Shunichi Ito (ORCID: https://orcid.org/0000-0002-8850-4566)
- Tatsuro Mutoh (ORCID: https://orcid.org/0000-0001-7712-8481)
- Sayuri Shima (ORCID: https://orcid.org/0000-0003-1761-0123)
- Yasuaki Mizutani (ORCID: https://orcid.org/0000-0002-5709-8526)
- Kazuki Nawashiro
- Akihiro Ueda (ORCID: https://orcid.org/0000-0002-9636-3011)
- T. NAKAI
Institutions
- Fujita Health University (JP)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1016/j.nbd.2025.107151
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00