Colony-stimulating factor-1 as a potential therapeutic target in asthenozoospermia
Seminal-plasma CSF-1 is a potential pathogenic factor in AZS. Its overexpression suppresses sperm motility by impairing mitochondrial energy metabolism. CSF-1 represents both a diagnostic biomarker and a promising therapeutic target (e.g., via Pexidartinib) for the clinical management of AZS. These findings provide a foundation for novel diagnostic and therapeutic strategies.
Authors
- Zhongyi Sun (ORCID: https://orcid.org/0000-0002-1285-2177)
- Hai‐Ning Liu (ORCID: https://orcid.org/0000-0001-7548-6269)
- Baoquan Han (ORCID: https://orcid.org/0000-0001-9490-1771)
- Yongyong Wang (ORCID: https://orcid.org/0000-0001-9444-1971)
- Cong Huang (ORCID: https://orcid.org/0000-0002-1119-431X)
- Qi Zhou (ORCID: https://orcid.org/0000-0003-4567-6525)
- Xiaodong Li (ORCID: https://orcid.org/0000-0001-8467-9679)
Institutions
- Qingdao University (CN)
- Shenzhen University (CN)
- Qingdao Municipal Hospital (CN)
- Peking University Shenzhen Hospital (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1186/s12958-025-01476-y
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shenzhen University