Association between incretin-related drugs and fractures in patients treated with pioglitazone: A pharmacovigilance study using the FDA Adverse Event Reporting System

Our results suggest that incretin-related drugs, especially GLP-1RAs, reduce the risk of fractures in patients treated with diabetes medications such as pioglitazone.

Authors

Katsuhiro Ohyama (ORCID: https://orcid.org/0000-0001-6307-577X)
Noriko Abe (ORCID: https://orcid.org/0000-0001-8314-6619)
Yusuke Hori (ORCID: https://orcid.org/0000-0002-5921-3479)
Takumi Okamoto

Publication Details

Journal: International Journal of Clinical Pharmacology and Therapeutics
Published: 2025-10-22
DOI: https://doi.org/10.5414/cp204789
Primary Topic: Pharmacovigilance and Adverse Drug Reactions
Type: article
Field-Weighted Citation Impact: 0.00

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article

Association between incretin-related drugs and fractures in patients treated with pioglitazone: A pharmacovigilance study using the FDA Adverse Event Reporting System

Katsuhiro Ohyama, Noriko Abe, Yusuke Hori, Takumi Okamoto

Oct 22, 2025

International Journal of Clinical Pharmacology and Therapeutics

Pharmacovigilance and Adverse Drug Reactions

article

Association between incretin-related drugs and fractures in patients treated with pioglitazone: A pharmacovigilance study using the FDA Adverse Event Reporting System

Katsuhiro Ohyama, Noriko Abe, Yusuke Hori, Takumi Okamoto

October 22, 2025article en

Abstract

Our results suggest that incretin-related drugs, especially GLP-1RAs, reduce the risk of fractures in patients treated with diabetes medications such as pioglitazone.

International Journal of Clinical Pharmacology and TherapeuticsVol. 64(01)

Openalex Percentile: Top 72%

Pharmacovigilance and Adverse Drug Reactions

DOI Source OpenAlex

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Association between incretin-related drugs and fractures in patients treated with pioglitazone: A pharmacovigilance study using the FDA Adverse Event Reporting System — Katsuhiro Ohyama, Noriko Abe, et al. · International Journal of Clinical Pharmacology and Therapeutics (2025) | TGRS Research Map | TGRS