iPSC-induced multilineage liver organoids, small intestinal organoids and brain organoids sustain pangenotype hepatitis E virus propagation
This study established iPSC-induced multilineage organoid infection models, confirming HEV's capacity for pan-tissue infection and revealing potential pathogenic mechanisms in the liver, intestine and nervous system. This platform provides valuable tools for HEV virology research and antiviral drug development, underscoring the unique value of organoid technology in infectious disease research.
Authors
- Pengyan Xia (ORCID: https://orcid.org/0000-0001-7959-5796)
- Chenyan Zhao (ORCID: https://orcid.org/0000-0002-1807-314X)
- Youchun Wang (ORCID: https://orcid.org/0000-0001-9769-5141)
- Lin Bai (ORCID: https://orcid.org/0000-0002-0220-6825)
- Jianhui Nie
- Fan Liu (ORCID: https://orcid.org/0000-0001-7118-4829)
- Guochao Wei (ORCID: https://orcid.org/0000-0002-7768-2404)
- Lili Wang (ORCID: https://orcid.org/0000-0002-0422-4277)
- Di Wu (ORCID: https://orcid.org/0000-0001-8209-4546)
- Jincheng Tong
- Weijin Huang (ORCID: https://orcid.org/0000-0002-4246-8889)
- Zizheng Zheng (ORCID: https://orcid.org/0000-0003-0099-4212)
- Tianxu Liu (ORCID: https://orcid.org/0009-0002-7973-4025)
- Lin Wang (ORCID: https://orcid.org/0000-0003-1555-9985)
- Kai Wang (ORCID: https://orcid.org/0000-0001-6240-0147)
- Zihao Yu
- Xi Wu (ORCID: https://orcid.org/0000-0002-9716-2772)
Institutions
- Xiamen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Tianjin International Joint Academy of Biomedicine (CN)
- SciTech Development (United States) (US)
- National Institutes for Food and Drug Control (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1136/gutjnl-2025-336105
- Citations
- 3
- Primary Topic
- Hepatitis Viruses Studies and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.97