Cardiometabolic multimorbidity, social activity, and joint trajectories of physical disability, depressive symptom, and cognitive function in mid-to-late life: a multicohort study
CMM was associated with worse levels, faster progression, and concurrent deterioration in physical disability, depressive symptom, and cognitive function, with the poorest trajectories among those who were socially inactive. This underscores the importance of implementing prevention strategies that integrate physical, psychological, cognitive, and social activities.
Authors
- Yaguan Zhou (ORCID: https://orcid.org/0009-0003-0802-9502)
- Mika Kivimaki B (ORCID: https://orcid.org/0000-0002-4699-5627)
- Xiaolin Xu (ORCID: https://orcid.org/0000-0002-8203-9878)
- Rodrigo M. Carrillo‐Larco (ORCID: https://orcid.org/0000-0002-2090-1856)
- Julianne Holt-Lunstad
- Yue Zhang (ORCID: https://orcid.org/0009-0000-2465-4621)
Institutions
- Brigham Young University (US)
- University of Helsinki (FI)
- Emory University (US)
- The University of Queensland (AU)
- Zhejiang Lab (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- University College London (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1186/s12916-025-04400-8
- Citations
- 7
- Primary Topic
- Chronic Disease Management Strategies
- Type
- article
- Field-Weighted Citation Impact
- 9.48
Funders
- China Medical Board
- Wellcome Trust
- National Natural Science Foundation of China
- Zhejiang University
- Medical Research Council
- Fundamental Research Funds for the Central Universities