Fingolimod Improves Anxiety-like Behavior and Modulates Sphingosine-1-Phosphate Receptors Gene Expression in a Diabetic Mouse Model
Results indicate an important role of S1PR modulation in T2DM. Moreover, fingolimod affected mRNA levels of proteins engaged in glucose metabolism/insulin signaling and improved the behavior of diabetic mice.
Authors
- Justyna Pyrzanowska
- Kamilla Blecharz‐Klin (ORCID: https://orcid.org/0000-0002-0990-3017)
- P.L. Wencel (ORCID: https://orcid.org/0000-0003-0587-2951)
- Agnieszka Piechal
- Robert P. Strosznajder (ORCID: https://orcid.org/0000-0002-1922-0295)
- Dagmara Mirowska-Guzeł (ORCID: https://orcid.org/0000-0001-6294-3256)
Institutions
- Medical University of Warsaw (PL)
- Mossakowski Medical Research Institute, Polish Academy of Sciences (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3390/biom15111485
- Citations
- 1
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Narodowym Centrum Nauki