Cold versus warm autoimmune hemolytic anemia in diffuse large B cell lymphoma: pathogenic and therapeutic implications: a case series
These cases reveal distinct molecular mechanisms (BCL6 versus BCL2/BCL6 amplification) and therapeutic vulnerabilities in autoimmune hemolytic anemia-diffuse large B cell lymphoma subtypes, requiring subtype-specific treatment. A screening triad-refractory hemolysis, cytopenia, and lymphatic/splenic involvement-enables early lymphoma detection. Molecular profiling may guide precision therapy, improving outcomes in this rare disease spectrum.
Authors
- Zhiye Zhang (ORCID: https://orcid.org/0000-0002-1661-2277)
- Xingxing Yu (ORCID: https://orcid.org/0000-0002-6370-3163)
- Tianwen Gao (ORCID: https://orcid.org/0000-0002-6899-2566)
- Jingjing Li (ORCID: https://orcid.org/0009-0001-9385-0535)
Institutions
- Fuyang Second People's Hospital (CN)
Publication Details
- Journal
- Journal of Medical Case Reports
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1186/s13256-025-05612-5
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui Medical University