Bruceine D inhibits hepatocellular carcinoma by regulating the STAT3 signaling pathway through HSP70
This study demonstrates that BD exerts potent antitumor effects against HCC by inhibiting proliferation, inducing apoptosis, and suppressing migration, primarily through disruption of the Hsp70/STAT3 signaling axis. With its favorable safety profile, BD represents a promising candidate for further development as a therapeutic agent in HCC.
Authors
- Min Zhao (ORCID: https://orcid.org/0000-0002-7422-6710)
- Shuling Wu (ORCID: https://orcid.org/0000-0001-6830-0075)
- Qingqing Lin
- Fanyun Zhu
- Bin Zhou (ORCID: https://orcid.org/0000-0002-1741-8628)
- Pu Chen (ORCID: https://orcid.org/0000-0002-6857-2211)
- Haiyang Zhao (ORCID: https://orcid.org/0000-0002-4396-7962)
- Qing Xu (ORCID: https://orcid.org/0000-0002-3183-5276)
- Yi Zhou (ORCID: https://orcid.org/0000-0002-5734-8855)
- Chengguang Zhao (ORCID: https://orcid.org/0000-0002-9981-0200)
- Ju Yang (ORCID: https://orcid.org/0009-0007-5098-8140)
Institutions
- Jiangnan University (CN)
- Wenzhou University (CN)
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Wuxi Fourth People's Hospital (CN)
- Yueqing People's Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1186/s40001-025-03270-3
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Medical University
- Wenzhou Municipal Science and Technology Bureau