Whole-genome sequencing reveals resistance mechanisms and molecular epidemiology of carbapenem-resistant Pseudomonas aeruginosa bloodstream infections
A very high genetic diversity was noted amongst P. aeruginosa strains isolated from BSIs cases. The mechanism of carbapenem resistance is mainly attributed to oprD mutations and efflux pumps activation, with carbapenemases emerging as an additional mechanism of concern. These resistance mechanisms with high-risk clinical factors collectively indicate that strict policies are essential for in CRPA BSIs management.
Authors
- Yihua Sun
- Yongqin Guo
- Yangyang Hao (ORCID: https://orcid.org/0009-0009-4374-1566)
- Dandan Wei (ORCID: https://orcid.org/0000-0002-5597-6233)
- Peng Liu
- Yang Liu (ORCID: https://orcid.org/0000-0002-0367-8189)
- Meng Huang (ORCID: https://orcid.org/0000-0001-9654-6195)
- Zhiju Tao
- S.D. Huang (ORCID: https://orcid.org/0000-0001-8046-3985)
Institutions
- Nanchang University (CN)
- China-Japan Friendship Hospital (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1186/s12866-025-04293-w
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- National Natural Science Foundation of China
- Nanchang University