Lamin A/C protects chromatin accessibility during mechanical loading in human skeletal muscle
Overall, lamin A/C deficiency amplifies the chromatin response to mechanical stress, leading to enhanced promoter accessibility and activation of stress DNA damage-related gene pathways. These findings underscore the role of lamin A/C in maintaining chromatin stability under mechanical strain.
Authors
- Eline Lemerle
- Marc Bitoun (ORCID: https://orcid.org/0000-0002-4188-7918)
- Catherine Coirault (ORCID: https://orcid.org/0000-0002-5594-1057)
- Natalia Pinzón (ORCID: https://orcid.org/0000-0002-0093-2487)
- Saline Jabre
- Emeline Cherchame (ORCID: https://orcid.org/0000-0002-4140-180X)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Holy Spirit University of Kaslik (LB)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut de Myologie (FR)
- Centre de Recherche Saint-Antoine (FR)
- Institut du Cerveau (FR)
- Centre de Recherche en Myologie
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1186/s12964-025-02437-z
- Citations
- 3
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Centre National de la Recherche Scientifique
- Faculty of Arts and Sciences